For the current analyses, data were available for 1,399,489 young adults (Table 1). Correlations (SE) of parental EB exposure were modest to moderate across time: r=0.48 (0.002) between ages 0–6 and 7–12; r=0.53 (0.002) between ages 7–12 and 13–18; and 0.41 (0.003) between ages 0–6 and 13–18. Individuals who had a parent with a history of EB during any developmental period were at increased risk for young adult AUD (Table 2), with the adjusted odds ratios (AORs) ranging from 2.29 to 2.44 for those with one period of exposure, increasing to AORs of 3.31 to 3.85 for those with two periods of exposure, and up to 4.84 for those exposed during all three periods. Preliminary analyses indicated that although young adult AUD was more common among men, there was no interaction between gender and exposure pattern (p = 0.85). Therefore, subsequent analyses included both men and women, with gender as a covariate.
