A twin-family study of alcoholism in women.
paper
Cited
Public
Unavailable
- Authors
- Kendler, K S; Neale, M C; Heath, A C; Kessler, R C; Eaves, L J
- Year
- 1994
- Journal
- The American journal of psychiatry
- PMID
- 8166312
- DOI
- 10.1176/ajp.151.5.707
OBJECTIVE: The authors seek to understand in general the sources of familial resemblance for alcoholism and in particular how parents transmit the vulnerability to alcoholism to their daughters. METHOD: The authors interviewed 1,030 pairs of female same-sex twins of known zygosity from the population-based Virginia Twin Registry and 1,468 of their parents. They examined a narrow definition of alcoholism, requiring tolerance or dependence, and a threshold approach that classified individuals either as unaffected or as suffering from one of three levels of severity of alcohol-related problems. Twin-family structural equation models were fitted to the observed tetrachoric or polychoric correlation matrices by using asymptotic weighted least squares. RESULTS: In the best-fitting model from both diagnostic approaches, 1) the familial resemblance for alcoholism was due to genetic factors, with the heritability of liability estimated at 51% to 59%; 2) genetic vulnerability to alcoholism was equally transmitted to daughters from their fathers and from their mothers; and 3) alcoholism in parents was not environmentally transmitted to their children. Assortative mating for alcoholism was found only for the broader definitions of illness. Genetic factors that influenced the liability to alcoholism were the same in the parental and twin generation for the narrow definition of alcoholism. When broader definitions were used, these factors, while substantially correlated, were not identical. CONCLUSIONS: The transmission of the vulnerability to alcoholism from parents to their daughters is due largely or entirely to genetic factors.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| <i>GDAP1</i> Is Dysregulated at DNA Methylation and H3K4me3 Levels in Alcohol Use Disorder. | Kawecka E et al. | — | 2025 | → |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | — | 2024 | → |
| Media framings of the role of genomics in "addiction" in the United States from 2015 to 2019: Individualized risk, biomedical expertise, and the limits of destigmatization. | Hendy K | — | 2024 | → |
| Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder. | Kendler KS et al. | — | 2024 | → |
| AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention. | Schuckit MA | — | 2022 | → |
| Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder. | Salvatore JE et al. | — | 2022 | → |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | — | 2021 | → |
| Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases. | Kapoor M et al. | — | 2021 | → |
| Variations of Brain Functional Connectivity in Alcohol-Preferring and Non-Preferring Rats with Consecutive Alcohol Training or Acute Alcohol Administration. | Liu Y et al. | — | 2021 | → |
| Associations of <i>BRAP</i> polymorphisms with the risk of alcohol dependence and scores on the Alcohol Use Disorders Identification Test. | Kim JW et al. | — | 2019 | → |
| Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol-Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort. | Meda SA et al. | — | 2019 | → |
| Extended Twin Study of Alcohol Use in Virginia and Australia. | Verhulst B et al. | — | 2018 | → |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | — | 2018 | → |
| Is family history of alcohol dependence a risk factor for disturbed sleep in alcohol dependent subjects? | Chakravorty S et al. | — | 2018 | → |
| A National Swedish Longitudinal Twin-Sibling Study of alcohol use disorders among males. | Long EC et al. | — | 2017 | → |
| Contributions of Genes and Environment to Developmental Change in Alcohol Use. | Long EC et al. | — | 2017 | → |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | — | 2017 | → |
| Individual differences in stress vulnerability: The role of gut pathobionts in stress-induced colitis. | Langgartner D et al. | — | 2017 | → |
| Maternal Problem Drinking and Child Mental Health. | Husky MM et al. | — | 2017 | → |
| Resilience and Risk for Alcohol Use Disorders: A Swedish Twin Study. | Long EC et al. | — | 2017 | → |
| The association between personality disorders with alcohol use and misuse: A population-based twin study. | Long EC et al. | — | 2017 | → |
| The genetics of alcohol dependence and alcohol-related liver disease. | Stickel F et al. | — | 2017 | → |
| Time-specific and cumulative effects of exposure to parental externalizing behavior on risk for young adult alcohol use disorder. | Edwards AC et al. | — | 2017 | → |
| Annual Research Review: On the developmental neuropsychology of substance use disorders. | Conrod PJ et al. | — | 2016 | → |
| Molecular genetic approaches to understanding the comorbidity of psychiatric disorders. | Gizer IR | — | 2016 | → |
| Comparison of Twin and Extended Pedigree Designs for Obtaining Heritability Estimates. | Docherty AR et al. | — | 2015 | → |
| Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults. | Long EC et al. | — | 2015 | → |
| Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. | Way M et al. | — | 2015 | → |
| No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls. | Müller KU et al. | — | 2015 | → |
| Triparental families: a new genetic-epidemiological design applied to drug abuse, alcohol use disorders, and criminal behavior in a Swedish national sample. | Kendler KS et al. | — | 2015 | → |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | — | 2014 | → |
| Alcohol dependence and reproductive timing in African and European ancestry women: findings in a midwestern twin cohort. | Waldron M et al. | — | 2014 | → |
| An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. | Olfson E et al. | — | 2014 | → |
| Association between HTR7 genetic polymorphisms and alcohol dependence, using the alcohol use disorders identification test (AUDIT). | Kim JH et al. | — | 2014 | → |
| Association study of DKK2 polymorphisms with alcohol dependence and alcohol-related harm. | Kim JY et al. | — | 2014 | → |
| Cognitive mediators and disparities in the relation between teen depressiveness and smoking. | Mistry R et al. | — | 2014 | → |
| Genetics of alcoholism. | Edenberg HJ et al. | — | 2014 | → |
| Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. | Kapoor M et al. | — | 2014 | → |
| Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. | Kos MZ et al. | — | 2014 | → |
| Suicidal behavior and haplotypes of the dopamine receptor gene (DRD2) and ANKK1 gene polymorphisms in patients with alcohol dependence--preliminary report. | Jasiewicz A et al. | — | 2014 | → |
| Use of animal models of alcohol-related behavior. | Crabbe JC | — | 2014 | → |
| A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. | Wang JC et al. | — | 2013 | → |
| Are there differences between young African-American and European-American women in the relative influences of genetics versus environment on age at first drink and problem alcohol use? | Sartor CE et al. | — | 2013 | → |
| Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. | Park BL et al. | — | 2013 | → |
| Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence. | Grzywacz A et al. | — | 2013 | → |
| Genetic and environmental influences on the relationship between mastery and alcohol dependence. | Kiecolt KJ et al. | — | 2013 | → |
| Genetics and alcoholism. | Edenberg HJ et al. | — | 2013 | → |
| Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. | Vereczkei A et al. | — | 2013 | → |
| The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. | Meyers JL et al. | — | 2013 | → |
| Bulimic behaviors and alcohol use: shared genetic influences. | Slane JD et al. | — | 2012 | → |
| Clinical indices of familial alcohol use disorder. | Kendler KS et al. | — | 2012 | → |
| Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. | Lin P et al. | — | 2012 | → |
| Environmental influences predominate in remission from alcohol use disorder in young adult twins. | McCutcheon VV et al. | — | 2012 | → |
| Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. | Wolen AR et al. | — | 2012 | → |
| Marijuana expectancies and relationships with adolescent and adult marijuana use. | Kristjansson SD et al. | — | 2012 | → |
| Neurobehavioral disinhibition predicts initiation of substance use in children with prenatal cocaine exposure. | Lester BM et al. | — | 2012 | → |
| Non-random mating and convergence over time for alcohol consumption, smoking, and exercise: the Nord-Trøndelag Health Study. | Ask H et al. | — | 2012 | → |
| Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. | Hurley LL et al. | — | 2012 | → |
| Subjective perceptions associated with the ascending and descending slopes of breath alcohol exposure vary with recent drinking history. | Wetherill L et al. | — | 2012 | → |
| Alcoholic marriage: later start, sooner end. | Waldron M et al. | — | 2011 | → |
| An internalizing pathway to alcohol use and disorder. | Hussong AM et al. | — | 2011 | → |
| Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women. | Sartor CE et al. | — | 2011 | → |
| Fatal alcohol intoxication in women: a forensic autopsy study from Slovakia. | Straka L et al. | — | 2011 | → |
| Heritability of problem drinking and the genetic overlap with personality in a general population sample. | de Moor MH et al. | — | 2011 | → |
| Predicting alcohol consumption in adolescence from alcohol-specific and general externalizing genetic risk factors, key environmental exposures and their interaction. | Kendler KS et al. | — | 2011 | → |
| Psychopathology in offspring from families of alcohol dependent female probands: a prospective study. | Hill SY et al. | — | 2011 | → |
| Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. | Evans SM et al. | — | 2011 | → |
| Stressing zebrafish for behavioral genetics. | Clark KJ et al. | — | 2011 | → |
| The Serotonin Transporter Polymorphism (5-HTTLPR) and Alcohol Problems in Heavy Drinkers: Moderation by Depressive Symptoms. | Tartter MA et al. | — | 2011 | → |
| Age at regular drinking, clinical course, and heritability of alcohol dependence in the San Francisco family study: a gender analysis. | Ehlers CL et al. | — | 2010 | → |
| A genome-wide association study of alcohol dependence. | Bierut LJ et al. | — | 2010 | → |
| Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction. | Getachew B et al. | — | 2010 | → |
| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. | Kalsi G et al. | — | 2010 | → |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | — | 2010 | → |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | — | 2010 | → |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Neural markers of genetic vulnerability to drug addiction. | Müller DJ et al. | — | 2010 | → |
| The moderating effect of religiosity on the genetic variance of problem alcohol use. | Button TM et al. | — | 2010 | → |
| A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. | Simpson TL et al. | — | 2009 | → |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | — | 2009 | → |
| [Genetic factors of alcohol-dependence]. | Pinto E et al. | — | 2009 | → |
| Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. | Bice P et al. | — | 2009 | → |
| The crown of love: intimate relations and alcohol use in adolescence. | van der Zwaluw CS et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents. | Heitzeg MM et al. | — | 2008 | → |
| Alcohol dependence and reproductive onset: findings in two Australian twin cohorts. | Waldron M et al. | — | 2008 | → |
| Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. | Tolstrup JS et al. | — | 2008 | → |
| Characteristics of monozygotic male and female twins discordant for overweight: a descriptive study. | Mitchell KS et al. | — | 2008 | → |
| Defining risk heterogeneity for internalizing symptoms among children of alcoholic parents. | Hussong AM et al. | — | 2008 | → |
| Density of familial alcoholism and its effects on alcohol use and problems in college students. | Capone C et al. | — | 2008 | → |
| Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. | Filbey FM et al. | — | 2008 | → |
| Disaggregating the distal, proximal, and time-varying effects of parent alcoholism on children's internalizing symptoms. | Hussong AM et al. | — | 2008 | → |
| Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches. | Sartor CE et al. | — | 2008 | → |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | — | 2008 | → |
| Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression. | Haughey HM et al. | — | 2008 | → |
| Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. | Agrawal A et al. | — | 2008 | → |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | — | 2008 | → |
| Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics. | Slutske WS et al. | — | 2008 | → |
| Sex differences in the heritability of alcohol problems. | Hardie TL et al. | — | 2008 | → |
| Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients. | Puls I et al. | — | 2008 | → |
| The tachykinin receptor 3 is associated with alcohol and cocaine dependence. | Foroud T et al. | — | 2008 | → |
| Association of alcohol craving with alpha-synuclein (SNCA). | Foroud T et al. | — | 2007 | → |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | — | 2007 | → |
| Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism. | Dai X et al. | — | 2007 | → |
| Spousal concordance for alcohol dependence: evidence for assortative mating or spousal interaction effects? | Grant JD et al. | — | 2007 | → |
| The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescence. | Button TM et al. | — | 2007 | → |
| Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. | Ishiguro H et al. | — | 2007 | → |
| Alcohol, tobacco and caffeine use: spouse similarity processes. | Reynolds CA et al. | — | 2006 | → |
| Association of the kappa-opioid system with alcohol dependence. | Xuei X et al. | — | 2006 | → |
| Assortative mating for cigarette smoking and for alcohol consumption in female Australian twins and their spouses. | Agrawal A et al. | — | 2006 | → |
| Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependence. | Button TM et al. | — | 2006 | → |
| Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. | Hinrichs AL et al. | — | 2006 | → |
| Genetics and alcoholism: how close are we to potential clinical applications? | Quickfall J et al. | — | 2006 | → |
| NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. | Ishiguro H et al. | — | 2006 | → |
| Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism. | Dai X et al. | — | 2005 | → |
| Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. | Haughey HM et al. | — | 2005 | → |
| Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens. | Tadic A et al. | — | 2005 | → |
| The contribution of genetics to addiction therapy approaches. | Edenberg HJ et al. | — | 2005 | → |
| Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. | Naassila M et al. | — | 2004 | → |
| Genetic and environmental contributions to age of onset of alcohol dependence symptoms in male twins. | Liu IC et al. | — | 2004 | → |
| Teenage drinking and the onset of alcohol dependence: a cohort study over seven years. | Bonomo YA et al. | — | 2004 | → |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | — | 2004 | → |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | — | 2003 | → |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | — | 2003 | → |
| Response to alcohol in females with a paternal history of alcoholism. | Evans SM et al. | — | 2003 | → |
| Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. | Saito T et al. | — | 2002 | → |
| Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history. | Dai X et al. | — | 2002 | → |
| Genetic polymorphism and American Indian health. | Long JC et al. | — | 2002 | → |
| The heritability of alcohol abuse and dependence: a meta-analysis of behavior genetic research. | Walters GD | — | 2002 | → |
| Genetic probes of three theories of maternal adjustment: II. Genetic and environmental influences. | Reiss D et al. | — | 2001 | → |
| Nature, nurture and mental disorder: old concepts in the new millennium. | Cooper B | — | 2001 | → |
| Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins. | Foley DL et al. | — | 2001 | → |
| The genetics of alcoholism and alcohol abuse. | Enoch MA et al. | — | 2001 | → |
| The relationship between cannabis use and other substance use in the general population. | Degenhardt L et al. | — | 2001 | → |
| Towards a molecular epidemiology of alcohol dependence: analysing the interplay of genetic and environmental risk factors. | Heath AC et al. | — | 2001 | → |
| Genes and addiction. | Nestler EJ | — | 2000 | → |
| Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins. | Prescott CA et al. | — | 1999 | → |
| D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. | Noble EP et al. | — | 1998 | → |
| Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. | Long JC et al. | — | 1998 | → |
| Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. | Streeter CC et al. | — | 1998 | → |
| Genetic and environmental influences on drug use and abuse/dependence in male and female twins. | van den Bree MB et al. | — | 1998 | → |
| Is a mild deficit in executive functions in boys related to childhood ADHD or to parental multigenerational alcoholism? | Wiers RW et al. | — | 1998 | → |
| A behavioral-genetic perspective on children of alcoholics. | McGue M | — | 1997 | → |
| Genetic markers of alcohol abuse. | Ferguson RA et al. | — | 1997 | → |
| Integration of generalized vulnerability to drug and alcohol addiction. | Miller NS et al. | — | 1997 | → |
| Predictors of the development of bulimia nervosa in women with anorexia nervosa. | Bulik CM et al. | — | 1997 | → |
| The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study. | Kendler KS et al. | — | 1997 | → |
| The genetic epidemiology of psychiatric disorders: a current perspective. | Kendler KS | — | 1997 | → |
| Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design. | Kendler KS et al. | — | 1996 | → |
| Predictors of tobacco quit attempts among recovering alcoholics. | Bobo JK et al. | — | 1996 | → |
| Quantitative trait locus gene mapping: a new method for locating alcohol response genes. | Crabbe JC | — | 1996 | → |
| Personality and the inheritance of smoking behavior: a genetic perspective. | Heath AC et al. | — | 1995 | → |
| Twin Study Design. | Prescott CA et al. | — | 1995 | → |