Bidirectional Mendelian randomisation was used to investigate previously-described relationships between mood disorder phenotypes (combined MDD, PGC BD) and external traits: schizophrenia, educational attainment, IQ, body mass index (BMI) and coronary artery disease (CAD; Figure 5, Supplementary Table 12). Associations with PGC BD should be interpreted cautiously, as only 19 loci reached genome-wide significance, several of which were removed as potentially pleiotropic in the analyses below.
