Chunk #29 — Results — Shared and distinct relationships with mood disorders and inferred causality

Source

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.

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A positive bidirectional relationship was observed between combined MDD and PGC BD, and between schizophrenia and both combined MDD and PGC BD. This is consistent with psychiatric disorders acting as causal risk factors for the development of further psychiatric disorders, or being correlated with other causal risk factors, including (but not limited to) the observed shared genetic basis.