Chunk #22 — METHODS — ORDINARY REGRESSION ON GENOTYPES AND ALLELIC DOSAGE — Additive

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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(3)yi=μ+βxi+εi, where ε ~ (0, σ2), independently for all i. We use OLS regression to test the null hypothesis H0: β = 0 vs. H1: β ≠ 0. To evaluate significance, we compute an F-statistic.