Chunk #23 — METHODS — ORDINARY REGRESSION ON GENOTYPES AND ALLELIC DOSAGE — Non-additive

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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Under a non-additive model, we expand xi to be composed of two components ( xi(1),xi(2)) as follows: (xi(1),xi(2))={(I{xi=1},I{xi=2})best−guessgenotype(p1i,p2i)genotypicdosage(I{gi=1},I{gi=2})truegenotype.