The final limitation of this study is that the rs9829896-KAT2B expression analysis of the BrainCloud data resulted in a P value that fell just at the 0.05 threshold for declaring statistical significance. We are not aware of any other currently available AA data sets to corroborate our eQTL finding. However, the consistency of rs9829896 association of expression across KAT2B, CREBBP, and OPRM1 among AAs and not in EAs lend some support to the potential of this SNP as tagging differences in expression of these drug abuse associated genes. Future gene expression studies using a large AA sample of prefrontal cortex and other addiction-relevant brain regions are needed.
