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Chunk #44 — DISCUSSION

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KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.
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statistical power (P=0.0019 to 0.015, Table S12) and very similar magnitudes of association (OR=0.53 to 0.55, Table S12). These results support the generalizability of this study’s genome-wide significant and replicated association to other drug abuse phenotypes, including DSM criteria. Other AA cohorts with a large number of DSM-IV or other defined abuse/dependence cases and nondependent controls would be appropriate for future replication testing of rs9829896.