In men, a somewhat different pattern of association with iSLE was observed. The full model accounted for 9.2%of the total variation in PYDD, with 5% attributable to demographic variables, 4% to the significant main effect of drinking onset, 0.02% to iSLE, and 0.2% to the independent effect of the onset × iSLE interactions. Despite the small R2, the interaction of ONS14 × iSLE was statistically significant (b = 0.27, SE = 0.13). As shown in Fig. 4B, compared to men who initiated drinking after age 14 and did not experience any past-year iSLE, those with a past-year iSLE and ONS14 consumed 1.2 additional drinks per week (4.3 drinks/wk for 0 iSLE vs. 5.5 drinks/wk for 1+ iSLE for onset ≤14). In the other onset groups, there was little effect of iSLE.
