Positive associations with AUD-related ICD codes were observed for both AUDIT-P (R2 = 0.18%, p < 2e-16) and AUDIT-C (R2 = 0.04%, p = 8.9e-5) PRS. For individuals in the top quartile of AUDIT-P PRS, the odds of having a mental or behavioral disorder due to alcohol was 1.45 (95% C.I. = 1.37–1.54) compared to those in the lowest quartile. For AUDIT-C PRS, being in the top PRS quartile was associated with an odds-ratio of 1.11 (95% C.I. = 1.02–1.20) compared to those in the lowest quartile (Figure 1). In the UKB, likelihood of AUD across quartiles seemed to follow a dose-response pattern with increasing OR for each quartile of polygenic risk for both AUDIT-C and AUDIT-P (though with overlapping C.I. for AUDIT-C), with the 4th quartile of AUDIT-P PRS being statistically significantly more likely to be diagnosed with AUD relative to the 3rd quartile.
