Chunk #34 — RESULTS — Associations between AUDIT PRS and onset of hazardous drinking and alcohol dependence — COGA:

Source

Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.

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The AUDIT-P, but not the AUDIT-C, PRS was associated with increased hazards of alcohol dependence onset (AUDIT-P HR = 1.15, 95% CI = 1.10–1.20, p = 4.7e-08; Supplemental Table 13). Those in the top quartile of AUDIT-P PRS were at considerably higher risk for onset of alcohol dependence (HR = 1.50, 95% CI = 1.36–1.64, p = 9.7e-10) relative to any other group; the risk attributable to the top AUDIT-C PRS was lower in magnitude (HR = 1.27, 95% CI = 1.14–1.40, p = 1.8e-4).