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Chunk #35 — RESULTS — Associations between AUDIT PRS and onset of hazardous drinking and alcohol dependence — ALSPAC:

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Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.
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Only the AUDIT-C PRS was associated with onset of hazardous drinking, although not significant after multiple testing corrections (Supplemental Table 14; AUDIT-C HR = 1.06, 95% CI = 1.02–1.10, p = 2.28e-3).