Meta-analyses were performed using METAL73 with effective sample size weighting. For all the case-control samples, we calculated effective sample size as:\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${n}_{\mathrm{effective}}=\frac{4}{\frac{1}{{n}_{\mathrm{case}}}+\frac{1}{{n}_{\mathrm{control}}}}$$\end{document}neffective=41ncase+1ncontrol
