For AUDIT–P in UKB, a continuous trait, we used actual sample sizes for meta-analysis. For all meta-analyses within or across ancestries, variants with a heterogeneity test P value <5 × 10−8 and variants with effective sample size <15% of the total effective sample size were removed. For the cross-ancestry and EUR within-ancestry meta-analyses, we required that variants were present in at least two cohorts. For the AFR and SAS within-ancestry meta-analyses, which are small samples, this was not required.
