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Chunk #10 — Materials and Methods — QUALITY CONTROL ANALYSES — SNPs — STAR*D

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Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
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DNA samples were genotyped on three related platforms: cases on Affymetrix 500K and 5.0, and controls on Affymetrix 6.0, resulting in 382,598 SNPs that were assayed on all three platforms and that passed QC for the MGS/GenRED controls. To ensure consistency of results, we then excluded SNPs for all samples in the STAR*D analysis based on cross-platform data as follows: