Chunk #21 — Results — Subgroups Based on Divisions of the PRS Distribution

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High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.

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Figure 4 shows an analysis of AOO for severe AUD in EA subjects using PRS quartiles. By the age of 25, 35% of subjects in the top quartile were diagnosed with severe AUD as compared with 16% of subjects in the bottom quartile. Subgroup analyses in AA subjects are presented in Figures S2–S5.