Chunk #20 — Results — Subgroups Based on Divisions of the PRS Distribution

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High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.

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Because AUC calculations do not capture the power of PRS at the extremes of the distribution, we plotted AOO for AUD in quartiles of EA PRS (Figure 3). Median AOO for subjects in the four quartiles were 20, 20, 22, and 24, respectively. By age 25, 72% of subjects in the highest quartile manifested AUD compared with 54% in the lowest quartile.