AUC peaks at 88% (all AUD) and 95% (severe AUD) for EA subjects (Table S2). Using a cut-point of 0.5, sensitivity is 72% and specificity is 87% at age 15. Sensitivity is 73% and specificity is 67% at age 20. In most models, peak AUC is achieved with inclusion of all variables. AUC power is primarily driven by the variable age of first drink, and the independent effects of other variables (including PRS) are generally small. PRS adds 8.6% to AUC by itself and 0.7% after all clinical variables in the integrated EA all AUD analysis; in the integrated EA severe AUD analysis, PRS adds 10.4% by itself but adds no additional variance following all clinical variables. AUC peaks at 88% (all AUD) and 92% (severe AUD) for AA subjects (Table S2). In the AA analyses, PRS adds 5.5% initially to all AUD and 13.5% initially to severe AUD but <1% when added after all clinical variables.
