Chunk #18 — Results — Combining PRSs With Demographic and Clinical Variables

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High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.

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As noted above, PRS was significantly associated with AOO covarying for sex, family type, and ancestry (Table 2). Adding in comorbid disorders, age of first drink, and peer drinking, PRS MAX_ALC.P1 remained associated with AOO of AUD in EA subjects (hazard ratio = 1.14, CI = 1.06−1.22, p = 2.11 × 10−4) (Table 3). For data in AA subjects, see Tables S1A and S1B. There is no significant relationship between PRS and AOO in AA subjects.