likely to play regulatory roles (Table 1). The number of cell lines in which the DNase clusters were observed is shown in Figures 1, 2, 3 as well as in the Figures S1, S2, S3. Histone marks are included in Figures 1, 2, 3 and Figures S1, S2, S3 but only those delineated in cell lines related to T cell and monocytes: a lymphocyte cell line (GM12878), a lymphoblastoid cell line, and K562, an erythroleukemia cell line. In several examples enrichment of particular histone marks coincides with differential methylation associated with CPA. The H3K4Me1 histone mark is mainly associated with enhancers and with DNA regions downstream of transcription start sites whereas H3K4Me3 is mainly associated with promoters and enhancers that are active or poised to be activated [71]. The H3K27Ac mark is thought to enhance transcription possibly by blocking the spread of the repressive histone mark H3K27Me3 [72].
