Chunk #12 — Results — Associations between Differentially Methylated Regions and Cytokine Levels

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Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression.

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Using previously measured cytokine protein levels in the same set of males [32], we were able to test for associations between DNA methylation and cytokine levels. Of the 48 differentially methylated regions associated with aggression, 7 regions were significantly correlated with cytokine levels encoded by the closest genes in blood plasma (FDR <0.2; Table 1). All but two were positively correlated with the cytokine levels in blood.