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Chunk #24 — DISCUSSION

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Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.
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We performed a genome-wide analysis of common copy number variations (CNVs) in two discovery samples ascertained for early-onset (extreme) obesity. We observed 244 CNVRs that covered ∼1.56% of the genome-most of these regions were already known from databases. Among the 244 CNVRs, we detected 20 regions that were directionally consistently associated with obesity in both discovery samples.