Chunk #23 — RESULTS — Previously reported CNVs in our genome-wide CNV analysis

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Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

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12 CNVs reported for patients with severe early-onset extreme obesity (20) were 133 kb downstream and 66 kb upstream of the CNVRs detected here (CNVR 3p11.1 and CNVR 15q13.2; Table 2). Both these CNVRs showed evidence for association with obesity in both of our GWAS discovery samples (3p11.1: min. Pfamily-based = 0.019; min. Pcc = 0.0072 for different CNV markers with maximum correlation r = 0.68; 15q13.2: min. Pfamily-based = 0.013; min. Pcc = 5.5 × 10−7 for different CNV markers with maximum correlation r = 0.70).