Chunk #25 — 3. Results — 3.2 Relationships between CNR1 tSNPs and brain volumes across marijuana misuse groupings

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Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

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After adjusting for multiple comparisons, the main effects of 3 CNR1 tSNPs on total cerebral WM brain volumes remained statistically significant (Table 3): rs7766029 (F=6.00, FDR-adjusted p=.05), rs12720071 (F=5.82, FDR-adjusted p=.05), and rs9450898 (F=8.24, FDR-adjusted p=.04). Pair-wise LD analysis of these 3 tSNPs found low inter-correlations (Table 1 and Figure 1; r2≤.07; Median r2=.02). For the other 7 tSNPs, there were no significant associations between CNR1 genotype and total cerebral WM or total cerebral GM brain volumes (Table 3; F≤2.34, FDR-adjusted p≥.13).