Three investigators (MS, PL, HJA) independently read the abstracts in order to select the publications of interest. Included in this study were original, randomized controlled trials (RCTs) comparing the efficacy of orally administered disulfiram to any control group. All studies included subjects with a diagnosis of alcohol abuse or dependence, whatever the classification system. In some studies, the primary inclusion criterion was cocaine dependence. In this case, we performed the analysis in the comorbid alcohol-cocaine subset. These studies consisted of blind and open-label designs, both supervised and unsupervised.
