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Chunk #26 — 4 Discussion

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.
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There are four major advantages of using our database and web interface: Users of LD Score regression currently spend most of their time reformatting, harmonizing and managing summary results data rather than running the ‘actual’ analyses. LD Hub minimizes the proportion of time spent on the former so that users can focus their attention on interpreting interesting genetic correlations and SNP heritability estimates.Users who do not have a computational background will find the interface easier to useThe software is computationally very fast. The current version (v1.0) can return the systematic analysis results to the user within a few hours. A queuing system has been introduced to prevent the server from crashing.As users upload and share their own summary GWAS results, the resource becomes increasingly useful.