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Chunk #25 — 4 Discussion

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LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.
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GWAS meta-analysis summary statistics are increasingly being made publicly available. Our database (currently) utilizes results from 173 different GWAS, which includes the majority of publicly available GWAS summary results suitable for LD Score regression (Bulik Sullivan et al., 2015a). However, this represents a small proportion of the traits represented in the GWAS Catalog (https://www.ebi.ac.uk/gwas/) (Hindorff et al., 2009; Welter et al., 2014). There is thus an urgent need for increased sharing of GWAS meta-analysis results in order to realize the full potential of techniques that utilize summary results data such as LD score regression. LD Hub provides a natural platform for the distribution of summary results data that can be utilized by the whole genetics community.