Genome-wide data from the CADD GWAS sample were further characterized using Genome-wide Complex Trait Analysis (GCTA; Yang et al. 2011). GCTA allows us to estimate the proportion of variance in the phenotype that may be explained using all of the genotyped SNPs using restricted maximum likelihood (REML) analysis. While this method does not specifically identify any causal variants, it does estimate the total proportion of sample variance that may be explained by all of the genotyped SNPs.
