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Chunk #34 — Results — Gene expression variation is associated to diverse traits

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.
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We downloaded summary statistics from meta analyses of over 100 phenotypes from 40 consortia. The full list of consortia and phenotypes is shown in Supplementary Data 2. We tested association between these phenotypes and the predicted expression levels using elastic net models in 44 human tissues from GTEx as described in the Methods section, and a whole blood model from the DGN cohort presented in ref. 11. We illustrate this application in Fig. 6b.