Data from these European-American ECA subjects was compared to data from European-American MNB research volunteers who provided informed consents, ethnicity data, drug use histories and DSMIII-R or IV diagnoses as previously described [6,31,32]. DNA in 34 pools sampled 400 "abusers" with heavy lifetime use of illegal substances and, for virtually all, DSMIII-R/IV dependence on at least one illegal abused substance and 280 "controls" who reported no significant lifetime use of any addictive substance. Generation and analyses of these data were approved by the NIH IRP (NIDA) IRB (protocol #148) and exempt protocols for pooled genotyping approved by the NIH Office of Human Research Subject Protection.
