The association between susceptibility alleles and fasting glucose, insulin and measures of insulin resistance and beta-cell function were tested in MAGIC [16]. This consortium includes data from 36,610 individuals of European descent who were included in 4 distinct consortia: [a] The European Network for Genetic and Genomic Epidemiology (ENGAGE) project, combining data from deCODE, Northern Finland Birth Cohort 1966, Netherlands Twins Register/Netherlands Study of Depression and Anxiety and the Rotterdam study; [b] the GEMS study, which includes data from the CoLaus and TwinsUK scans; [c] DFS, which includes the DGI, FUSION and SardiNIA scans; and [d] the Framingham Heart Study. Details of all of these studies, phenotyping and genotyping protocols have been published previously [16].
