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Chunk #60 — Methods — Developmental and Cellular Expression Profiles

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A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.
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Spatiotemporal transcriptomic atlas from Kang et al., 201112 was used to obtain cortical expression profiles across multiple developmental stages. Developmental stages were defined as follows: stage 1, 4 PCW ≤ Age < 8 PCW; stage 2, 8 PCW ≤ Age < 10 PCW; stage 3, 10 PCW ≤ Age < 13 PCW; stage 4, 13 PCW ≤ Age < 16 PCW; stage 5, 16 PCW ≤ Age < 19 PCW; stage 6, 19 PCW ≤ Age < 24 PCW; stage 7, 24 PCW ≤ Age < Birth; stage 8, Birth ≤ Age < 6 M; stage 9, 6M ≤ Age < 1 Y; stage 10, 1 Y ≤ Age < 6 Y; stage 11, 6 Y ≤ Age < 12 Y; stage 12, 12 Y ≤ Age < 20 Y; stage 13, 20 Y ≤ Age < 60 Y; stage 14, Age > 60 Y.