Among these substances, worldwide cannabis is the most widely used illicit drug [5]. Cannabis use (CU) in the United States is reported to be 11.8% in individuals older than 12 years and 10.8% in those individuals aged 26 years and older [5,6]. The CU rate in adults aged 26 and older increased from 7.9% to 10.8% from 2017 to 2020. Cannabis use disorders (CUDs) were diagnosed in 13.5% in 18–25-year-olds and 4.0% in those individuals aged 26+ years. By comparison, among European adults, past-month prevalence of CU increased by 27% from 2010–2019 (from 3.1 to 3.9%), with the most pronounced relative increases observed among 35–64-year-olds [7].
