Chunk #52 — ONLINE METHODS — Integration of GWA findings to tissue and cellular gene expression

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

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We conducted a transcriptome wide association study50 using pre-computed expression reference weights for CMC data (5,420 genes with significant cis-SNP heritability) provided with the TWAS/FUSION software. The significance threshold was 0.05/5420.