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Chunk #32 — 4. DISCUSSION

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Neuropsychological performance of South African treatment-naïve adolescents with alcohol dependence.
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In contrast to Moss et al.’s (1994) findings that 14–15-year-old AD participants made fewer perseverative and commission errors than controls, our AD participants demonstrated poorer self-monitoring and regulation abilities. Our study confirmed US findings (Nigg et al., 2006; Tarter et al., 1995) that AD is associated with poorer ability to inhibit prepotent responses, which is one of the indicators of neurobehavioral disinhibition that might render adolescents vulnerable to adolescent substance involvement (Clark et al., 2005). In our sample, it is unclear whether the inhibitory difficulties precede or follow the onset of AD.