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Chunk #40 — RESULTS — Predicting a patient’s responsiveness to Li according to electrophysiological measurements

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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.
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and ‘hypo’ neurons. The LR group changes in the sodium and fast AHP between ‘hyper’ and ‘hypo’ neurons are somewhere between the control and NR groups. The differences in the basic features and currents between the three groups of control, LR and NR neurons, may explain not only the average larger excitability of NR and LR neurons but also the larger diversity of the BD, and especially NR BD, excitability phenotype. For example, the total number of evoked action potentials in the NR neurons for the entire data set was 39.2 ± 5.4, whereas it was 20.6 ± 1.7 in the controls, with the average larger, but also a much larger coefficient of variation in the NR group (0.14 NR vs 0.08 control).