To summarize, the functional features that characterize the hyperexcitable neurons include larger sodium currents that open at a less depolarized potential (~ −50 mV), larger fast potassium currents that also open at a less depolarized potential (~ −30 mV), larger sodium-to-potassium ratio and a larger capacitance. The typical spike shape of the hyperexcitable neurons is a larger amplitude narrower spike with a less depolarized threshold for evoking an action potential and a very large increase in the fast AHP amplitude. While these features characterize a hyperexcitable neuron, the diversity of these features within the population changes in the three groups of control, LR and NR neurons. The control neurons changes between the ‘hyper’ and ‘hypo’ neurons, is most pronounced in the fast AHP, whereas in the NR group the largest changes are found in the sodium currents when comparing ‘hyper’ and ‘hypo’ neurons. The LR group changes in the sodium and fast AHP between ‘hyper’ and ‘hypo’ neurons are somewhere between the control and NR groups. The differences in the basic features and currents between the three groups of control,
