As shown in Fig 1A, ethanol feeding induced formation of lipid droplets in liver of both Cyp2a5+/+ mice and Cyp2a5−/− mice, but the percentage of hepatocytes containing lipid droplets was higher in Cyp2a5−/− mice than in Cyp2a5+/+ mice (Fig. 1B). Consistently, liver TG contents were increased in Cyp2a5−/− mice to a greater extent than in Cyp2a5+/+ mice (Fig 1C grey bars). In a similar manner, serum levels of TG were increased in Cyp2a5−/− mice but not in Cyp2a5+/+ mice (Fig 1C black bars). These results suggest that ablation of CYP2A5 promotes alcoholic fatty liver.
