In summary, in accordance with previous studies, our data on multiethnic populations further confirmed that rs2476601 (R620W) is unequivocally associated with SLE in individuals with European ancestry. Additionally, since rs2476601 was associated with aCL IgG our data suggests that this PTPN22 variant might be associated with pathogenesis of antiphospholipid syndrome in Europeans. We also detected significant association with rs3765598 in HS, though no significant associations were observed in AA or AS. Further, independent replication studies are required in these populations to establish these novel associations with SLE and its clinical sub-phenotypes and autoantibody status.
