PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
paper
Cited
Public
- Authors
- Namjou, Bahram; Kim-Howard, Xana; Sun, Celi; Adler, Adam; Chung, Sharon A; Kaufman, Kenneth M; Kelly, Jennifer A; Glenn, Stuart B; Guthridge, Joel M; Scofield, Robert H; Kimberly, Robert P; Brown, Elizabeth E; AlarcΓ³n, Graciela S; Edberg, Jeffrey C; Kim, Jae-Hoon; Choi, Jiyoung; Ramsey-Goldman, Rosalind; Petri, Michelle A; Reveille, John D; VilΓ‘, Luis M; Boackle, Susan A; Freedman, Barry I; Tsao, Betty P; Langefeld, Carl D; Vyse, Timothy J; Jacob, Chaim O; Pons-Estel, Bernardo; Argentine Collaborative Group; Niewold, Timothy B; Moser Sivils, Kathy L; Merrill, Joan T; Anaya, Juan-Manuel; Gilkeson, Gary S; Gaffney, Patrick M; Bae, Sang-Cheol; AlarcΓ³n-Riquelme, Marta E; BIOLUPUS and GENLES Networks; Harley, John B; Criswell, Lindsey A; James, Judith A; Nath, Swapan K
- Year
- 2013
- Journal
- PloS one
- PMID
- 23950893
- DOI
- 10.1371/journal.pone.0069404
- PMCID
- PMC3737240
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk allele frequency differs dramatically across ethnicities, we assessed robustness of PTPN22 association with SLE and its clinical sub-phenotypes across four ethnically diverse populations. Ten SNPs were genotyped in 8220 SLE cases and 7369 controls from in European-Americans (EA), African-Americans (AA), Asians (AS), and Hispanics (HS). We performed imputation-based association followed by conditional analysis to identify independent associations. Significantly associated SNPs were tested for association with SLE clinical sub-phenotypes, including autoantibody profiles. Multiple testing was accounted for by using false discovery rate. We successfully imputed and tested allelic association for 107 SNPs within the PTPN22 region and detected evidence of ethnic-specific associations from EA and HS. In EA, the strongest association was at rs2476601 (P = 4.7 Γ 10(-9), OR = 1.40 (95% CI = 1.25-1.56)). Independent association with rs1217414 was also observed in EA, and both SNPs are correlated with increased European ancestry. For HS imputed intronic SNP, rs3765598, predicted to be a cis-eQTL, was associated (P = 0.007, OR = 0.79 and 95% CI = 0.67-0.94). No significant associations were observed in AA or AS. Case-only analysis using lupus-related clinical criteria revealed differences between EA SLE patients positive for moderate to high titers of IgG anti-cardiolipin (aCL IgG >20) versus negative aCL IgG at rs2476601 (P = 0.012, OR = 1.65). Association was reinforced when these cases were compared to controls (P = 2.7 Γ 10(-5), OR = 2.11). Our results validate that rs2476601 is the most significantly associated SNP in individuals with European ancestry. Additionally, rs1217414 and rs3765598 may be associated with SLE. Further studies are required to confirm the involvement of rs2476601 with aCL IgG.
The haplotype structure of select SNPs from the PTPN22 region in EA controls.Blocks connecting SNP pairs are shaded according to the strength of the linkage disequilibrium (r2).
Minor allele frequency of rs2476601 and rs1217414 as a function of proportion of European admixture for SLE cases and healthy controls.
1β20 of 31
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| ArechigaAF, HabibT, HeY, ZhangX, ZhangZY, et al (2009) Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol 182: 3343β3347.1926511010.4049/jimmunol.0713370PMC2797545 | β | β | β |
| BarrettJC, FryB, MallerJ, DalyMJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263β265.1529730010.1093/bioinformatics/bth457 | β | β | β |
| BegovichAB, CarltonVE, HonigbergLA, SchrodiSJ, ChokkalingamAP, et al (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 75: 330β337.1520878110.1086/422827PMC1216068 | β | β | β |
| BehrensTW (2011) Lyp breakdown and autoimmunity. Nat Genet 43: 821β822.2187403310.1038/ng.914 | β | β | β |
| BottiniN, MusumeciL, AlonsoA, RahmouniS, NikaK, et al (2004) A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nat Genet 36: 337β338.1500456010.1038/ng1323 | β | β | β |
| BrownlieRJ, MiosgeLA, VassilakosD, SvenssonLM, CopeA, et al (2012) Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal 5: ra87.2319316010.1126/scisignal.2003365PMC5836999 | β | β | β |
| BurnGL, SvenssonL, Sanchez-BlancoC, SainiM, CopeAP (2011) Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett 10.1016/j.febslet.2011.04.03221515266 | β | β | β |
| CambierJC (2013) Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways. J Clin Invest 123: 1928β1931.2361935910.1172/JCI69289PMC3635745 | β | β | β |
| CantonI, AkhtarS, GavalasNG, GawkrodgerDJ, BlomhoffA, et al (2005) A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Genes Immun 6: 584β587.1601536910.1038/sj.gene.6364243 | β | β | β |
| CooperGS, ParksCG, TreadwellEL, St ClairEW, GilkesonGS, et al (2002) Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States. Lupus 11: 161β167.1199988010.1191/0961203302lu161oa | β | β | β |
| CriswellLA, PfeifferKA, LumRF, GonzalesB, NovitzkeJ, et al (2005) Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Am J Hum Genet 76: 561β571.1571932210.1086/429096PMC1199294 | β | β | β |
| CurtinK, WongJ, Allen-BradyK, CampNJ (2007) Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1. BMC Proc 1 Suppl 1: S12.1846646110.1186/1753-6561-1-s1-s12PMC2367587 | β | β | β |
| DaiX, JamesRG, HabibT, SinghS, JacksonS, et al (2013) A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 123: 2024β2036.2361936610.1172/JCI66963PMC3638909 | β | β | β |
| Diaz-GalloLM, GourhP, BroenJ, SimeonC, FonollosaV, et al (2011) Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Ann Rheum Dis 70: 454β462.2113164410.1136/ard.2010.130138PMC3170726 | β | β | β |
| DrenkardC, VillaAR, Alarcon-SegoviaD, Perez-VazquezME (1994) Influence of the antiphospholipid syndrome in the survival of patients with systemic lupus erythematosus. J Rheumatol 21: 1067β1072.7932417 | β | β | β |
| DultzG, MatheisN, DittmarM, BenderK, KahalyGJ (2009) CTLA-4 CT60 polymorphism in thyroid and polyglandular autoimmunity. Horm Metab Res 41: 426β429.1953027010.1055/s-0029-1214414 | β | β | β |
| FernandezM, AlarconGS, Calvo-AlenJ, AndradeR, McGwinGJr, et al (2007) A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE. Arthritis Rheum 57: 576β584.1747152410.1002/art.22672 | β | β | β |
| GianchecchiE, PalombiM, FierabracciA (2012) The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity. Autoimmun Rev 10.1016/j.autrev.2012.12.00323261816 | β | β | β |
| GomezLM, AnayaJM, GonzalezCI, Pineda-TamayoR, OteroW, et al (2005) PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Genes Immun 6: 628β631.1616337310.1038/sj.gene.6364261 | β | β | β |
| GregersenPK, LeeHS, BatliwallaF, BegovichAB (2006) PTPN22: setting thresholds for autoimmunity. Semin Immunol 18: 214β223.1673100310.1016/j.smim.2006.03.009 | β | β | β |
| HanJW, ZhengHF, CuiY, SunLD, YeDQ, et al (2009) Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet 41: 1234β1237.1983819310.1038/ng.472 | β | β | β |
| HarrisEN, GharaviAE, PatelSP, HughesGR (1987) Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol 68: 215β222.3652514PMC1542695 | β | β | β |
| HindorffLA, SethupathyP, JunkinsHA, RamosEM, MehtaJP, et al (2009) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 106: 9362β9367.1947429410.1073/pnas.0903103106PMC2687147 | β | β | β |
| HinksA, BartonA, JohnS, BruceI, HawkinsC, et al (2005) Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Arthritis Rheum 52: 1694β1699.1593409910.1002/art.21049 | β | β | β |
| HochbergMC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725.10.1002/art.17804009289324032 | β | β | β |
| JagielloP, AriesP, ArningL, WagenleiterSE, CsernokE, et al (2005) The PTPN22 620W allele is a risk factor for Wegener's granulomatosis. Arthritis Rheum 52: 4039β4043.1632035210.1002/art.21487 | β | β | β |
| KaufmanKM, KellyJA, HerringBJ, AdlerAJ, GlennSB, et al (2006) Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum 54: 2533β2540.1686897410.1002/art.21963 | β | β | β |
| KimK, BrownEE, ChoiCB, Alarcon-RiquelmeME, KellyJA, et al (2012) Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 71: 1809β1814.2252342810.1136/annrheumdis-2011-201110PMC3466387 | β | β | β |
| KyogokuC, LangefeldCD, OrtmannWA, LeeA, SelbyS, et al (2004) Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet 75: 504β507.1527393410.1086/423790PMC1182029 | β | β | β |
| LeaW, LeeY (2011) The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. Lupus 20: 51β57.2107876610.1177/0961203310381774 | β | β | β |
| LeeYH, RhoYH, ChoiSJ, JiJD, SongGG, et al (2007) The PTPN22 C1858T functional polymorphism and autoimmune diseasesβa meta-analysis. Rheumatology (Oxford) 46: 49β56.1676019410.1093/rheumatology/kel170 | β | β | β |
| LessardCJ, AdriantoI, KellyJA, KaufmanKM, GrundahlKM, et al (2011) Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet 88: 83β91.2119467710.1016/j.ajhg.2010.11.014PMC3014359 | β | β | β |
| Manjarrez-OrdunoN, MarascoE, ChungSA, KatzMS, KiridlyJF, et al (2012) CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet 44: 1227β1230.2304211710.1038/ng.2439PMC3715052 | β | β | β |
| McClainMT, ArbuckleMR, HeinlenLD, DennisGJ, RoebuckJ, et al (2004) The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 50: 1226β1232.1507730510.1002/art.20120 | β | β | β |
| MenardL, SaadounD, IsnardiI, NgYS, MeyersG, et al (2011) The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J Clin Invest 121: 3635β3644.2180419010.1172/JCI45790PMC3163953 | β | β | β |
| MoriM, YamadaR, KobayashiK, KawaidaR, YamamotoK (2005) Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. J Hum Genet 50: 264β266.1588385410.1007/s10038-005-0246-8 | β | β | β |
| OrozcoG, SanchezE, Gonzalez-GayMA, Lopez-NevotMA, TorresB, et al (2005) Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 52: 219β224.1564106610.1002/art.20771 | β | β | β |
| OrruV, TsaiSJ, RuedaB, FiorilloE, StanfordSM, et al (2009) A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet 18: 569β579.1898106210.1093/hmg/ddn363PMC2722189 | β | β | β |
| PetriM, Perez-GutthannS, LongeneckerJC, HochbergM (1991) Morbidity of systemic lupus erythematosus: role of race and socioeconomic status. Am J Med 91: 345β353.195137810.1016/0002-9343(91)90151-m | β | β | β |
| PiotrowskiP, LianeriM, WudarskiM, LackiJK, JagodzinskiPP (2008) Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland. Clin Exp Rheumatol 26: 1099β1102.19210878 | β | β | β |
| PloskiR, DziunyczP, KostrzewaG, RoszkowskiPI, BarczE, et al (2009) PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population. J Reprod Immunol 79: 196β200.1923720310.1016/j.jri.2008.11.004 | β | β | β |
| PradhanV, BorseV, GhoshK (2010) PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility. J Postgrad Med 56: 239β242.2073978010.4103/0022-3859.68651 | β | β | β |
| PriceAL, PattersonNJ, PlengeRM, WeinblattME, ShadickNA, et al (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904β909.1686216110.1038/ng1847 | β | β | β |
| PritchardJK, RosenbergNA (1999) Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 65: 220β228.1036453510.1086/302449PMC1378093 | β | β | β |
| PurcellS, DalyMJ, ShamPC (2007) WHAP: haplotype-based association analysis. Bioinformatics 23: 255β256.1711895910.1093/bioinformatics/btl580 | β | β | β |
| PurcellS, NealeB, Todd-BrownK, ThomasL, FerreiraMA, et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559β575.1770190110.1086/519795PMC1950838 | β | β | β |
| ReddyMV, JohanssonM, SturfeltG, JonsenA, GunnarssonI, et al (2005) The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1. Genes Immun 6: 658β662.1605217210.1038/sj.gene.6364252 | β | β | β |
| ReveilleJD, MouldsJM, AhnC, FriedmanAW, BaethgeB, et al (1998) Systemic lupus erythematosus in three ethnic groups: I. The effects of HLA class II, C4, and CR1 alleles, socioeconomic factors, and ethnicity at disease onset. LUMINA Study Group. Lupus in minority populations, nature versus nurture. Arthritis Rheum 41: 1161β1172.966347110.1002/1529-0131(199807)41:7<1161::AID-ART4>3.0.CO;2-K | β | β | β |
| Rodriguez-RodriguezL, TaibWR, ToplessR, SteerS, Gonzalez-EscribanoMF, et al (2011) The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Arthritis Rheum 63: 365β372.2127999310.1002/art.30145 | β | β | β |
| SanchezE, ComeauME, FreedmanBI, KellyJA, KaufmanKM, et al (2011) Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study. Arthritis Rheum 63: 3493β3501.2179283710.1002/art.30563PMC3205224 | β | β | β |
| SiminovitchKA (2004) PTPN22 and autoimmune disease. Nat Genet 36: 1248β1249.1556510410.1038/ng1204-1248 | β | β | β |
| SkinningsrudB, HusebyeES, GervinK, LovasK, BlomhoffA, et al (2008) Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Eur J Hum Genet 16: 977β982.1830144410.1038/ejhg.2008.33 | β | β | β |
| SLEGENHarley JB, Alarcon-RiquelmeME, CriswellLA, JacobCO, et al (2008) Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40: 204β210.1820444610.1038/ng.81PMC3712260 | β | β | β |
| SmithRL, WarrenRB, EyreS, KeX, YoungHS, et al (2008) Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Br J Dermatol 158: 962β968.1834166610.1111/j.1365-2133.2008.08482.xPMC2342636 | β | β | β |
| TanEM, CohenAS, FriesJF, MasiAT, McShaneDJ, et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25: 1271β1277.713860010.1002/art.1780251101 | β | β | β |
| TotaroMC, TolussoB, NapolioniV, FaustiniF, CanestriS, et al (2011) PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis. PLoS One 6: e24292.2194970210.1371/journal.pone.0024292PMC3174938 | β | β | β |
| VandiedonckC, CapdevielleC, GiraudM, KrumeichS, JaisJP, et al (2006) Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis. Ann Neurol 59: 404β407.1643756110.1002/ana.20751 | β | β | β |
| VangT, CongiaM, MacisMD, MusumeciL, OrruV, et al (2005) Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 37: 1317β1319.1627310910.1038/ng1673 | β | β | β |
| VangT, LandskronJ, VikenMK, OberprielerN, TorgersenKM, et al (2013) The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Hum Immunol 10.1016/j.humimm.2012.12.017PMC401117323333624 | β | β | β |
| VelagaMR, WilsonV, JenningsCE, OwenCJ, HeringtonS, et al (2004) The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. J Clin Endocrinol Metab 89: 5862β5865.1553155310.1210/jc.2004-1108 | β | β | β |
| YangLi, DingJ, AbecasisGR (2006) Mach 1.0: Rapid Haplotype Reconstruction and Missing Genotype Inference. Am J Hum Genet S79: 2290. | β | β | β |
| YooYJ, GaoG, ZhangK (2007) Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. BMC Proc 1 Suppl 1: S33.1846653110.1186/1753-6561-1-s1-s33PMC2367547 | β | β | β |
| ZellerT, WildP, SzymczakS, RotivalM, SchillertA, et al (2010) Genetics and beyondβthe transcriptome of human monocytes and disease susceptibility. PLoS One 5: e10693.2050269310.1371/journal.pone.0010693PMC2872668 | β | β | β |
| ZhangJ, ZahirN, JiangQ, MiliotisH, HeyraudS, et al (2011) The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 43: 902β907.2184177810.1038/ng.904 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | 2016 | 26202629 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Advances in the management of systemic lupus erythematosus. | Morand EF et al. | β | 2023 | β |
| Gene Expression and Autoantibody Analysis Revealing Distinct Ancestry-Specific Profiles Associated With Response to Rituximab in Refractory Systemic Lupus Erythematosus. | Carter LM et al. | β | 2023 | β |
| Deconvoluting the heterogeneity of SLE: The contribution of ancestry. | Owen KA et al. | β | 2022 | β |
| Genetic Polymorphism of <i>PTPN22</i> in Autoimmune Diseases: A Comprehensive Review. | Tizaoui K et al. | β | 2022 | β |
| What can we learn from DNA methylation studies in lupus? | FerretΓ©-Bonastre AG et al. | β | 2022 | β |
| Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview. | Gachpazan M et al. | β | 2021 | β |
| Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus. | Ukadike KC et al. | β | 2021 | β |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. | Hou G et al. | β | 2021 | β |
| Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility. | Wang YF et al. | β | 2019 | β |
| Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications. | Solouki S et al. | β | 2019 | β |
| The study of interactions between genome and exposome in the development of systemic lupus erythematosus. | Leffers HCB et al. | β | 2019 | β |
| Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond. | Kwon YC et al. | β | 2019 | β |
| A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. | Patel ZH et al. | β | 2018 | β |
| High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility. | Al-Awadhi AM et al. | β | 2018 | β |
| Novel missense mutation in PTPN22 in a Chinese pedigree with Hashimoto's thyroiditis. | Gong L et al. | β | 2018 | β |
| Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease. | Aflatounian M et al. | β | 2017 | β |
| Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis. | Hu LY et al. | β | 2017 | β |
| Characterization of the Asian Phenotype - An Emerging Paradigm with Clinicopathological and Human Research Implications. | Leow MK | β | 2017 | β |
| Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus. | Aterido A et al. | β | 2017 | β |
| Human papilloma virus and lupus: the virus, the vaccine and the disease. | Segal Y et al. | β | 2017 | β |
| Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders. | Ferluga J et al. | β | 2017 | β |
| PTPN22 1858Cβ>βT polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update. | de Lima SC et al. | β | 2017 | β |
| The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. | LΓ³pez-Cano DJ et al. | β | 2017 | β |
| Updates in Lupus Genetics. | Deng Y et al. | β | 2017 | β |
| Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus. | Rupasree Y et al. | β | 2016 | β |
| Distribution of PTPN22 polymorphisms in SLE from western Mexico: correlation with mRNA expression and disease activity. | Machado-Contreras JR et al. | β | 2016 | β |
| Genetic Polymorphism (rs329498) in the Pellino-1 Gene as Possible Predisposal Factor for Systemic Lupus Erythematosus in a Chinese Population. | Ni J et al. | β | 2016 | β |
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | β | 2016 | β |
| PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population. | Tang L et al. | β | 2016 | β |
| The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children. | Abdelrahman HM et al. | β | 2016 | β |
| The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned. | Teruel M et al. | β | 2016 | β |
| Advances in lupus genetics. | Niewold TB | β | 2015 | β |
| Association of PTPN22 polymorphsims and ankylosing spondylitis susceptibility. | Meng Q et al. | β | 2015 | β |
| Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. | Bentham J et al. | β | 2015 | β |
| IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups. | Elghzaly AA et al. | β | 2015 | β |
| Lupus Nephritis: A Different Disease in European Patients? | Tesar V et al. | β | 2015 | β |
| PTPN22 Variant R620W Is Associated With Reduced Toll-like Receptor 7-Induced Type I Interferon in Systemic Lupus Erythematosus. | Wang Y et al. | β | 2015 | β |
| Recent advances in systemic lupus erythematosus genetics in an Asian population. | Lee HS et al. | β | 2015 | β |
| The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus. | Maine CJ et al. | β | 2015 | β |
| A variant within intron 1 of the PTPN22 gene decreases the genetic susceptibility of ankylosing spondylitis in a central south Chinese Han population. | Tang L et al. | β | 2014 | β |
| Clinical perspectives on lupus genetics: advances and opportunities. | James JA | β | 2014 | β |
| PTPN22: the archetypal non-HLA autoimmunity gene. | Stanford SM et al. | β | 2014 | β |
| The effect of inversion at 8p23 on BLK association with lupus in Caucasian population. | Namjou B et al. | β | 2014 | β |