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Chunk #11 — Results

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PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
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A total of 7427 EA (3936 cases and 3491 controls), 3338 AA (1527 cases and 1811 controls), 2525 AS (1265 cases and 1260 controls), and 2299 HS (1492 cases and 807 controls) passed QC and were used for association analyses. All ten genotyped SNPs passed QC in EA and HS, though rs2476601 was monomorphic in AS and AA, and rs33996649 failed genotyping in AA and AS. Using our genotypes and 1000Genomes Project data, 109 to 165 SNPs were imputed (165 in AA, 113 in EA, 109 in HS, and 101 in AS). Of these, a total of 107 SNPs passed QC (81 in AA, 83 in EA, 83 HS, and 79 AS).