In this study we investigated association PTPN22 variants in SLE cases and healthy controls in four diverse ethnic populations in order to elucidate the population specific relationship between different PTPN22 SNPs and disease risk. Genetic associations were examined in European-Americans (EA), African-Americans (AA), Asians (AS), and Hispanics (HS). Our results confirm SLE association with missense rs2476601 in EA, and we identified association of rs3765598 with SLE in HS. No significant associations were observed in AA or AS.
