The endophenotypes described in this special section were initially conceived and selected two decades ago, around the time the Human Genome Project began. Nevertheless, many of our endophenotypes were as much measures of basic brain function then as they are now. We therefore contend that the present findings are highly relevant to current endophenotypic research including exciting new efforts to identify neural systems involved in behavior and psychiatric disorder such as the RDoC (Insel et al., 2010), insofar as investigators attempt to understand the genetic architecture of those systems.
