In aggregate, there were fewer significant and biologically plausible associations than might be expected, if one assumes that endophenotypes will provide greater power to identify genes relevant for psychiatric disease or behavioral traits. Given the results reported in this special issue, this assumption may be unrealistic for these psychophysiological endophenotypes, although one might contend that they remain relatively complex and genetically distal measures of basic brain function and task-related brain activity. At the very least, one may conclude the endophenotypic increase in power to detect genes is not great enough to be observed in a sample of the size reported here (N < 4,500).
