with genes that are relevant in metabolic phenotypes, such as cholesterol levels. In the GTEx data, rs4731702 is in strong linkage disequilibrium with two variants, rs13234269 and rs35722851 (R2 =0.98 and 0.99, respectively), that are cis-eQTLs for KLF14 in subcutaneous adipose (P ≤2.2×10−5 and P ≤4.7×10−5, respectively). We evaluated the association of rs13234269 with all expressed genes in GTEx subcutaneous adipose (17,633 genes). Although we found no individually significant trans-eGenes, we found an enrichment of association with distal gene expression in subcutaneous adipose tissue (π1 =0.07, after PEER correction), replicating the results of the MuTHER study.
