All stem cell work was performed with approval from UC Irvine Human Stem Cell Research Oversight (hSCRO) and IBC committees. The use of human fibroblast and PBMC samples for iPSC reprogramming and differentiation was approved by the University of California, Irvine Institutional Review Board (IRB Protocol #2013-9561) and informed consent was obtained from all subjects. Human iPSC cell lines ADRC 2 (Male), 4 (Male), 5 (Female), 12 (Male), 14 (Male), 20 (Female), 22 (Female), 76 (Male), 85 (Female), and 86 (Female) were generated by the UCI Alzheimer’s Disease Research Center (ADRC) Induced Pluripotent Stem Cell Core using non-integrating Sendai virus (Cytotune) and are available to other researchers via http://stemcells.mind.uci.edu/. iPSCs were confirmed to be sterile and karyotypically normal via G-banding (WiCell.org). Pluripotency of all lines was confirmed via (http://pluritest.org) and further confirmed using the Human Pluripotent Stem Cell Functional Identification Kit (R&D Systems), per manufacturer’s instructions.
