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Chunk #19 — RESULTS — Prioritisation by Gene Expression

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Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
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After removing duplicates, there were 55 SMR/SMR-Hi-C prioritised genes (Supplementary Table 12) of which 46 were protein-coding. Genes where putatively causal eQTLs captured a particularly high FINEMAP PP (>95%) (Supplementary Table 17g) include ACE encoding angiotensin converting enzyme, the target of a major class of anti-hypertensive drugs (schizophrenia under-expression), DCLK3 encoding a neuroprotective kinase29(schizophrenia under-expression) and SNAP91 (discussed below; schizophrenia over-expression).