et al., 2005). Three other SNPs located in intron-3 and intron-4 were nominally associated with the factAD4 and sumAD4 measures. Similar levels of association (p < 0.05) were observed for four of the SNPs with the closely related “sum of DSM-IIIR AD symptoms” phenotype (data not shown). The “total” association results for the quantitative measures shown in Table 3 were non-significant. Although the “within” association is not significant after taking account of multiple testing (with a threshold level of significance set at 0.00045, see Subjects and Methods), multiple studies reporting association between GABRA2 and AD have been published. Our results provide limited support for a role of GABRA2 in risk for alcoholism.
