info Tables S1, S2 and Figs. S1, S2). Finally, we derived a PRS for risky behaviors from a GWAS of the first prinicipal component of four risky behaviors (drinks per week, ever smoking, propensity for driving over the speed limit, and number of sexual partners) from 315,894 individuals in the UK Biobank (UKB)13. While this PRS does include alcohol consumption and smoking, it captures the shared variance between these substance use measures and the other two risky behaviors. These polygenic scores covered the domains of alcohol consumption (GSCAN DPW), alcohol problems (PROB ALC), and general externalizing (RISK PC).
