We used four primary discovery GWASs to create three different PRSs. The first was from a recent GWAS of number of alcoholic drinks per week in approximately one million individuals provided by the GWAS & Sequencing Consortium of Alcohol and Nicotine Use (GSCAN)8. We obtained GSCAN summary statistics with all Finnish (which included FinnTwin12) and 23andMe (which are not publicly available) cohorts removed (available N = 534,683). The PRS for alcohol problems were derived from a meta-analysis of two GWASs: a GWAS on the problem subscale from the Alcohol Use Disorders Identification Test (questions 4–10; AUDIT-P) in 121,604 individuals from the UK Biobank6 and the Psychiatric Genomcs Consurtium’s (PGC) GWAS of alcohol dependence (N = 46,568)5. Both FT12 and COGA were in the initial AD GWAS and we obtained summary statistics with each cohort removed (meta-analysis results available in supplemental info Tables S1, S2 and Figs. S1, S2). Finally, we derived a PRS for risky behaviors from a GWAS of the first prinicipal component of four risky behaviors (drinks per week, ever smoking, propensity for driving over the speed limit,
